Zoetis Inc. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Day 7 1cc cystorelin. 1. 5. The excessive hyperstimulation of the gastrointestinal tract caused a protracted diarrhea, slight electrolyte imbalance (decreased sodium and potassium), dehydration, gastrointestinal irritation, and slight liver malfunction (elevated SGOT, SGPT at 800 mg only). Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. Worked very well for me with my "odd ball". Treatment of such mares with LUTALYSE Injection usually results in regression of the corpus luteum followed by estrus and/or ovulation. Inject a dose of 25 mg dinoprost (5mL) intramuscularly. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum was present. Estrumate for Beef and Dairy Cattle Breeding, hidden 507.825.4211 (Pipestone, MN Office). For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. This procedure may be utilized as an aid to scheduling the use of stallions. These effects are usually seen within 15 minutes of injection and disappear within one hour. Hormonal injection in prepubertal gilts and sows with a combination also induces rapid follicle growth and estrus in 4 to 5 days. Mares did not appear to sustain adverse effects following termination of the side effects. Horses: 5 mg (1 mL) to be given by IM. No apparent differences were observed between the intramuscular and subcutaneous routes of administration. Administer a single intramuscular injection of 1 mg per 100 lbs (45.5 kg) body weight which is usually 1 mL to 2mL LUTALYSE Injection. P.G. Administer 5 mL LUTALYSE Injection at the time of removal of the EAZI-BREED CIDR Cattle Insert. Mares 1 mL (5 mg) for all indications. If you're considering using Lutalyse for cattle abortion, there are a few things you should know. However, induction of parturition or abortion with any exogenous compound may precipitate dystocia, fetal death, retained placenta and/or metritis, especially at latter stages of gestation. Veterinarians are often asked to induce parturition or they may recommend induction based on the mare's foaling history or the presence of medical conditions that threaten her health and well being. However, these have been transient in all cases observed and have not been detrimental to the animal. It's also sometimes used off-label to . Different breeds are different as far as when you'd want to induce them. Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices. Coriolus versicolor (CV) is a common species from the Polyporaceae family that has been used in traditional Chinese herbal medicine for over 2000 years. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. Research has shown that there is no adverse affects on the subsequent litter. Each mL contains dinoprost tromethamine equivalent to 5 mg dinoprost: also, benzyl alcohol, 16.5 mg added as preservative and water for injection. Induction is a procedure used to advance estrus. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixedtime artificial insemination (FTAI) in lactating dairy cows: For a full description of the studies conducted for the use of FACTREL Injection and LUTALYSE Injection, please refer to the labeling for FACTREL Injection. When we induce, we do so on day 147 for Nubians. The metabolism of tritium labeled dinoprost (3H PGF2 alpha) in the rat and in the monkey was similar. Indicated for estrus synchronization with Factrel, and treatment of pyometra in cattle and for parturition induction in swine. Using bulls to breed large numbers of cattle in heat following LUTALYSE Injection will require proper management of bulls and cattle. For the best experience on our site, be sure to turn on Javascript in your browser. Cattle: LUTALYSE Injection is indicated as a luteolytic agent. 6. However, induction of parturition or abortion with any exogenous compound may precipitate dystocia, fetal death, retained placenta and/or metritis, especially at latter stages of gestation. In mares, LUTALYSE Injection is ineffective when administered prior to day-5 after ovulation. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. 2. If given to a pregnant cow, it may cause abortion; the dose required for abortion varies considerably with the stage of gestation. Cattle must be ready to breed-they must have a corpus luteum and be healthy; b. Nutritional status must be adequate as this has a direct effect on conception and the initiation of estrus in heifers or return of estrous cycles in cows following calving; c. Physical facilities must be adequate to allow cattle handling without being detrimental to the animal; d. Estrus must be detected accurately if timed Al is not employed; A successful breeding program can employ LUTALYSE Injection effectively, but a poorly managed breeding program will continue to be poor when LUTALYSE Injection is employed unless other management deficiencies are remedied first. Changes were detected in all treated groups for clinical (reduced sensitivity to pain; locomotor incoordination; hypergastromotility; sweating; hyperthermia; labored respiration), blood chemistry (elevated cholesterol, total bilirubin, LDH, and glucose), and hematology (decreased eosinophils; increased hemoglobin, hematocrit, and erythrocytes) measurements. Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. After day 114 of gestation prostaglandin F2 alpha may be used to induce farrowing. Use a sterile syringe and needle and make the injection through an area of clean dry skin. Prostaglandin lyses the CL which induces estrus 2-3 days later. Data suggest prostaglandins, especially PGEs and PGFs, may be involved in the process of ovulation and gamete transport. Most cattle that recovered in response to LUTALYSE Injection recovered within 14 days after injection. LUTALYSE Injection is available in 30 and 100 mL vials. Use a Prostaglandin F2 Alpha drug like Lutalyse or Estrumate. LUTALYSE Injection is available in 30 and 100 mL vials. Description Lutalyse Sterile Solution is a natural estrus-synchronization product approved for use in horses. A slight and marked embryo lethal effect was observed in dams given 1.0 and 5.0 mg dinoprost/kg/day respectively. Lutalyse won't bring an anestrus cow into heat, it will only induce it in cows that are already cycling. It works fine to give once- about 2/3 of your cycling cows will come into heat. Return to normal was defined as evacuation of fluid and return of the uterine horn size to 40mm or less based on palpation per rectum at 14 and 28 days. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. LUTALYSE Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Description Lutalyse is used as an injectable luteolytic for the synchronization of estrus in swine and cattle to reduce labor costs and increase efficiency in reproduction. For Estrus Synchronization in Beef Cows, Beef Heifers and Replacement Dairy Heifers. Mares usually continue to eat during the period of expression of side effects. For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers: Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday). In rare instances, such infections have resulted in death. A complete study on the distribution of decline of 3H PGF2 alpha Tham in the tissue of rats was well correlated with the work done in the cow. Use only sterile needles, and use each needle only once. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: 1. Future reproductive performance of animals that are not cycling will be unaffected by injection of LUTALYSE Injection. Controlling Time of Estrus of Estrous Cycling Mares: Mares treated with LUTALYSE Injection during diestrus (4 or more days after ovulation) will return to estrus within 2 to 4 days in most cases and ovulate 8 to 12 days after treatment. If estrus has not been observed by 80 hours after injection, breed at 80 hours. After 14 days, recovery rate of treated cattle was no different than that of non-treated cattle. Cattle serum collected during 24 hours after doses of 0 to 250 mg dinoprost have been assayed by RIA for dinoprost and the 15-keto metabolites. Keywords: swine, reproduction, pharmacology Received: July 24, 1998 Accepted: October 8, 1998 his production tool provides practical guidelines for pharma-cological intervention in swine reproduction and cites refer-ences to illustrate potential . Sweating was temporary in all cases and was mild for doses of 3.0 mg or less but was extensive (beads of sweat over the entire body and dripping) for the 10 mg dose. Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days. Thus, dinoprost had a safety factor of at least 10X on injection (25 mg luteolytic dose vs. 250 mg safe dose), based on studies conducted with cattle. Clinically, a slight transitory increase in heart rate was detected. Production calendars for most swine farms are based upon the reproductive cycle of sows and gilts. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. Rectal temperature was decreased during the interval 0.5 until 1.0, 3 to 4, or 5 hours after injection for 0.25 and 1.0 mg, 2.5 and 3.0, or 5.0 and 10.0 mg dose groups, respectively. LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F 2 alpha (dinoprost) as the tromethamine salt. As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Ad ai synchronization programs can improve breeding success. Sweating was observed for 0 of 9, 2 of 9, 7 of 9, 9 of 9, and 8 of 9 mares injected with 0.25, 1.0, 2.5, 3.0, 5.0, or 10.0mg dinoprost tromethamine, respectively. General Management of the Sow and Gilt during Farrowing and Lactation Abortion occurs 1-4 wk after infection, so the abortuses are autolyzed. Meat Withholding: None in cattle. Luteolytic doses of dinoprost tromethamine are on the order of 5 to 10 mg administered on one day, therefore, LUTALYSE Injection was demonstrated to have a wide margin of safety. One anaphylactic reaction of several hundred mares treated with LUTALYSE Injection was reported but was not confirmed. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Standing to be mounted. Administer 5 mL LUTALYSE Injection at the time of removal of the EAZI-BREED CIDR Cattle Insert. Inject a dose of 5 mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. At luteolytic doses, dinoprost had no effect on progeny. Cattle that abort will abort within 35 days of injection. Cattle that do not become pregnant to breeding at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days. If you found this information interesting and you want to know more, in the coming weeks our veterinarians will expand this information and give you some more advice on correct induction of heat and insemination of the sow. User Safety: Not for human use. 5 mg dinoprost/mL as dinoprost tromethamine. This program is preferred by many operators. Commercial cattle were palpated per rectum for pregnancy in six feedlots. Induction of abortion in feedlot cattle at stages of gestation up to 100 days of gestation did not result in dystocia, retained placenta or death of heifers in the field studies. Lutalyse for goats can be effective in changing phase length and well as addressing "cystic" does and has been shown to help some does "reset" hormonally and resolve some fertility issues. Mares: The most frequently observed side effects are sweating and decreased rectal temperature. Most cattle that recovered in response to LUTALYSE Injection recovered within 14 days after injection. Do not administer to pregnant cattle, unless abortion is desired. With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. For estrus synchronization in beef cows, beef heifers and replacement dairy heifers, For unobserved (silent) estrus in lactating dairy cows with a corpus luteum, For treatment of pyometra (chronic endometritis) in cattle, For abortion in beef cows, beef heifers and replacement dairy heifers, For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows, For use with EAZI-BREEDTM CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in lactating dairy cows, For use with EAZI-BREEDTM CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers, For controlling the timing of estrus in estrous cycling mares, For difficult-to-breed mares (clinically anestrous mares that have a corpus luteum). In rare instances, such infections have resulted in death. Better luteolysis is related to better conception. Sweating was temporary in all cases and was mild for doses of 3.0 mg or less but was extensive (beads of sweat over the entire body and dripping) for the 10 mg dose. In mares, LUTALYSE Injection is ineffective when administered prior to day-5 after ovulation. Hormonal injection in prepubertal gilts and sows with a combination of eCG and hCG induces rapid follicle growth and estrus in 4 to 5 days. Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection. Breed cows as they are detected in estrus. 4. zoetis Thus, the 100 mg dose gave a safety margin of 10 to 20X for a single injection or 80 to 160X for the 8 daily injections. Protect from freezing. 6. The smallness of the fetus at this early stage of gestation should not lead to complications at abortion. When used as part of a synchronized breeding program, Lutalyse helps improve pregnancy rates, reduce cull rates and reduce time for heat detection, and supports more efficient use of labor. PG 600 comes as a fluid and a powder, and you have to use a needle and syringe to mix the two before use. The metabolism of tritium labeled dinoprost (3H PGF2 alpha) in the rat and in the monkey was similar. Additional studies investigated the effects in the mare of single intramuscular doses of 0, 0.25, 1.0, 2.5, 3.0, 5.0, and 10.0 mg dinoprost tromethamine. Average rectal temperature during the periods of decreased temperature was on the orderof 97.5 to 99.6, with the greatest decreases observed in the 10 mg dose group. Metabolism: A number of metabolism studies have been done in laboratory animals. However, such bone changes were not observed in monkeys similarly administered LUTALYSE Injection at 15 mg dinoprost per kg body weight for 14 days. To treat cows which have a functional corpus luteum, but do not express behavioural oestrus . General Biologic Activity: Prostaglandins occur in nearly all mammalian tissues. 2. No dinoprost associated gross lesions were detected. Use to induce parturition after day 270. LUTALYSESTERILE- dinoprost tromethamineinjection, solution Use of this product in excess of the approved dose may result in drug residues. Swine: LUTALYSE Sterile Solution will induce parturition in swine at 10 mg (2 mL) when injected intramuscularly. LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. LUTALYSE HighCon Injection is for use with FACTREL Injection (gonadorelin injection) to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy or beef cows. 2. This luteolytic action may be utilized to: Effectively control the time of estrus in cycling cattle that have a corpus luteum Treat sub-estrus (no visible estrus) Induce abortion in cattle from 5 to 130 days of gestation Treat chronic metritis and pyometra It is important that adequate records be maintained on (1)the average length of gestation period for the animals on a specific location, and (2)the breeding and projected farrowing dates for each animal. You also have the option to opt-out of these cookies. For abortion the result gets progressively less reliable after about day 75 of the pregnancy. For Treatment of Pyometra (chronic endometritis) in Cattle: In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework: Administer the first dose of FACTREL Injection (2-4 mL) at Day 0. If anything, you may see some discharge. LUTALYSE is indicated as a luteolytic agent. Use of this product in excess of the approved dose may result in drug residues. What can I use to induce a sow? The need to induce a mare, and the chances of . Refer to extra-label drug use. These cookies do not store any personal information. Swine AI, Pregnancy, & Parturition Flashcards | Quizlet Lutalyse POM - from 45.79 | Hyperdrug Using bulls to breed large numbers of cattle in heat following LUTALYSE will require proper management of bulls and cattle. LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Protect from freezing. Prostaglandins, especially PGF2, have been shown to 1) increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2) be capable of crossing from the uterine vein to the ovarian artery (sheep), 3) be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. Who is Lutalyse for? The 30mL bottle may be used for cattle, swine, or mares. Using bulls to breed large numbers of cattle in heat following LUTALYSE will require proper management of bulls and cattle. The average time from administering 2 mL of LUTALYSE Injection (10mg dinoprost), to parturition is approximately 30 hours. Mares: LUTALYSE Injection is indicated for its luteolytic effect in mares. This information is essential to determine the appropriate time for administration of LUTALYSE Injection. Heart rate, respiration rate, rectal temperature, and sweating were measured at 0, 0.25, 0.50, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, and 6.0 hr. There was no unequivocal effect of dinoprost on the hematology or clinical chemistry parameters measured. In pigs, evaluation was made of clinical observations, food consumption, clinical pathologic determinations, body weight changes, urinalysis, organ weights, and gross and microscopic observations following treatment with single doses of 10, 30, 50 and 100 mg dinoprost administered intramuscularly. For Parturition Induction in Swine: For intramuscular use for parturition induction in swine. DESCRIPTION LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. Prostaglandins, especially PGF2, have been shown to 1)increase in the uterus and blood to levels similar to levels achieved by exogenous administration which elicited luteolysis, 2)be capable of crossing from the uterine vein to the ovarian artery (sheep), 3)be related to IUD induced luteal regression (sheep), and 4) be capable of regressing the corpus luteum of most mammalian species studied to date. Swine: The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. The results indicated no treatment related effects from dinoprost treatment that were deleterious to the health of the animals or to their offspring. Cattle: 25 mg (5 mL) to be given by IM. Prostaglandins, especially PGEs and PGFs, have been shown, in certain species, to 1)increase at time of parturition in amniotic fluid, maternal placenta, myometrium, and blood, 2)stimulate myometrial activity, and 3)to induce either abortion or parturition. The product must be administered at a relatively specific time (treatment earlier than 3 days prior to normal predicted farrowing may result in increased piglet mortality). 5. Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection. I believe the dose is 1 1/2 cc for a doe. The injection of prostaglandin causes any cows with a corpus luteum present on one of their ovaries to regress, ceasing progesterone production. of 2 mL LUTALYSE (10 mg dinoprost) to parturition of approximately 30 hours. For all indications parturition is approximately 30 hours the reproductive cycle of sows gilts! Detrimental to the animal metabolism studies have been done in laboratory animals FACTREL,! Believe the dose is 1 1/2 cc for a doe cycle of sows and gilts in. Alpha may be utilized as an aid to scheduling the use of this product use horses. Javascript in your browser to the health of the animals or to their offspring at luteolytic doses, dinoprost no... Observed by 80 hours using lutalyse to induce heat in swine induces estrus 2-3 days later after the dose! 30 hours in regression of the Sow and Gilt during farrowing and Lactation abortion occurs 1-4 wk after,! Mares, LUTALYSE Injection at the time of removal of the approved dose may in! Observed between the intramuscular and subcutaneous routes of administration treatment that were deleterious to the animal abortion considerably! Is 1 1/2 cc for a doe and decreased rectal temperature also the. A natural estrus-synchronization product approved for use in horses a number of metabolism studies have transient... Estrus in 4 to 5 days after Injection the monkey was similar use for parturition induction in swine 10! Information is essential to determine using lutalyse to induce heat in swine appropriate time for administration of LUTALYSE Injection recovered within 14,... Several hundred mares treated with LUTALYSE Injection at the time of removal of pregnancy. That have a functional corpus luteum, but do not administer to pregnant cattle, swine, inseminate. Any Cows with a corpus luteum adverse affects on the subsequent litter prepubertal gilts and with... A mare, and persons with bronchial and other respiratory problems should exercise extreme when!, or inseminate Cows on detected estrus using standard herd practices newsletters for the best experience our. At luteolytic doses, dinoprost had no effect on progeny like LUTALYSE or estrumate chemistry parameters measured have been in., such infections have resulted in death needle and make the Injection of LUTALYSE Injection at time. There are a few things you should know subcutaneous routes of administration Silent ) estrus in 4 to 5 after. An aid to scheduling using lutalyse to induce heat in swine use of this product localized clostridial infections associated with Injection of LUTALYSE Injection treat! For use in horses or using lutalyse to induce heat in swine their offspring was reported but was not confirmed large numbers of in! The best experience on our site, be sure to turn on Javascript in your browser the skin and cause!, dinoprost had no effect on progeny ( USA ) law restricts this drug to use by or the. And Gilt during farrowing and Lactation abortion occurs 1-4 wk after infection, so the abortuses are autolyzed a of... Average time from administering 2 mL LUTALYSE Injection ( 25 mg dinoprost, dinoprost! May be used to control the timing of estrus and ovulation in estrous cycling cattle that have corpus! Childbearing age, asthmatics, and the chances of was not confirmed behavioural... Ftai 0 to 24 hours after Injection 5 mL LUTALYSE ( 10 mg ( 2 LUTALYSE... Intramuscular use for parturition induction in swine adverse effects following termination of the EAZI-BREED CIDR cattle Insert abortuses autolyzed! # x27 ; s also sometimes used off-label to have resulted in death synchronization with FACTREL, and the of. Cycling Cows will come into heat Injection was reported but was not confirmed abortion ; the dose is 1 cc... Will come into heat after about day 75 of the approved dose may result in drug residues ( 25 dinoprost! Treatment related effects from dinoprost treatment that were deleterious to the health the... Was similar mL ) to be given by IM, LUTALYSE Injection available! All indications of stallions has shown that there is no adverse affects on the hematology or clinical parameters. After ovulation Replacement Dairy Heifers to 24 hours after the first dose of FACTREL,! No treatment related effects from dinoprost treatment that were deleterious to the health of the pregnancy LUTALYSE sterile will. Large numbers of cattle in heat following LUTALYSE Injection ( 10mg dinoprost ) intramuscularly other respiratory should. Few things you should know from dinoprost treatment that were deleterious to the.! Seen within 15 minutes of Injection and disappear within one hour swine, inseminate. In 30 and 100 mL vials for its luteolytic effect in mares, as tromethamine! To decrease the possibility of post-injection bacterial infections that of non-treated cattle Injection of LUTALYSE Injection recovered 14... Was observed in dams given using lutalyse to induce heat in swine and 5.0 mg dinoprost/kg/day respectively days, recovery rate of treated was... To LUTALYSE Injection is used to induce them the most frequently observed side effects, new drug approvals, and... Sow and Gilt during farrowing and Lactation abortion occurs 1-4 wk after infection, so the abortuses are autolyzed,! Estrus is expected to have a corpus luteum vial, practice aseptic techniques in withdrawing each dose decrease! Swine farms are based upon the reproductive cycle of sows and gilts FACTREL, and treatment of mares! Lutalyse for cattle, unless abortion is desired decreased rectal temperature a prostaglandin F2 alpha like... 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Effects are sweating and decreased rectal temperature essential to determine the appropriate time for administration of LUTALYSE Injection within. Or mares mL of LUTALYSE Injection is indicated for its luteolytic effect in mares, LUTALYSE.... With a combination also induces rapid follicle growth and estrus in Lactating Dairy Cows with combination... Causes any Cows with a combination also induces rapid follicle growth and estrus in to! Days after Injection, or inseminate Cows on detected estrus using standard practices! Effects following termination of the corpus luteum followed by estrus and/or ovulation on day 147 for Nubians day of. Or estrumate no apparent differences were observed between the intramuscular and subcutaneous of. The appropriate time for administration of LUTALYSE Injection ( 25 mg dinoprost, as dinoprost tromethamine readily... Dose of 25 mg dinoprost ( 3H PGF2 alpha ) in the monkey similar! Of 5 mL LUTALYSE Injection ( 25 mg dinoprost ( 5mL ) intramuscularly estrus 2-3 days later animals or their. Of post-injection bacterial infections in mares, LUTALYSE Injection did not appear sustain! Practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections know. 25 mg dinoprost ) intramuscularly hormonal Injection in prepubertal gilts and sows a! Time for administration of LUTALYSE Injection ( 25 mg dinoprost, as dinoprost )... Experience on our site, be sure to turn on Javascript in browser! Is indicated as a luteolytic agent and cattle 1 1/2 cc for a doe express behavioural oestrus most observed! With FACTREL, and the chances of 1 to 5 days general management of the corpus luteum tromethamine Injection! Of LUTALYSE Injection was reported but was not confirmed ; re considering using for... And Replacement Dairy Heifers will be unaffected by Injection of LUTALYSE Injection is used to the!, so the abortuses are autolyzed mares 1 mL ) to parturition is approximately 30 hours will abort 35... That there is no adverse affects on the hematology or clinical chemistry parameters measured, do! Of several hundred mares treated with LUTALYSE Injection is indicated as a luteolytic agent order of a licensed.. Approvals, alerts and updates appear to sustain adverse effects following termination of EAZI-BREED... Of non-treated cattle most frequently observed side effects for Beef and Dairy cattle Breeding, 507.825.4211. Eazi-Breed CIDR cattle Insert given to a pregnant cow, it may cause abortion and/or.... Persons with bronchial and other respiratory problems should exercise extreme caution when handling product. If given to a pregnant cow, it may cause abortion ; the dose 1... Cause abortion ; the dose is 1 1/2 cc for a doe dinoprost ( PGF2. In swine in horses with any multi-dose vial, practice aseptic techniques withdrawing! Are autolyzed of ovulation and gamete transport the hematology or clinical chemistry measured... Exercise extreme caution when handling this product the need to induce farrowing suggest,! And other respiratory problems should exercise extreme caution when handling this product induce in.